Preface: Many companies do not plan to use the Microsoft IIS web server until MS SharePoint is born.
MS SharePoint baseline design: If you decide to use SharePoint, IIS web server will be work with you forever. Indeed that SharePoint products are popular. And such away let people forget about IIS web server weakness. Perhaps most of the design architect conduct the preventive control to avoid the risk already. They install a proxy server in front of IIS.
Doubt: If you have proxy server in front of IIS web server. Do you jeopardize by this vulnerability?
Perhaps your proxy will be reduce the risk. But for the long run. Schedule to do the patching.
Below is the official announcement by Microsoft.
ADV190005 – Guidance to adjust HTTP/2 SETTINGS frames